Test Method
IHC
CPT Code
88342 x 1
88341 x 1
Stains / Test Description
p16 (p16 -INK4a, p16-MTS1, inhibitor of CDK4) is the product of the CDKN2 gene. It inhibits the progression of the cell cycle through the G1 phase. p16 is a candidate tumor suppressor, whose gene is frequently deleted or mutated in tumors such as melanomas, gliomas, esophageal, pancreatic, lung, and urinary bladder carcinomas, and some types of leukemias. p16 expression is associated with high-risk human papillomavirus in cervical cancer and head and neck tumors.
Specimen Requirements
(1) H&E slide with formalin-fixed, paraffin-embedded (FFPE) tissue, fixed with 10% NBF.
or
One (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4 microns) for each test/antibody ordered
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
or
One (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4 microns) for each test/antibody ordered
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Storage & Transport
Ship specimen same day (whenever possible) with refrigerated (not frozen) cold pack
Turnaround time
1-3 days depending on level of service
Level of Service
Global (with interpretation)
Slide Only (glass slides only)
Web-Enabled (glass and digital images through eCSI portal)
Slide Only (glass slides only)
Web-Enabled (glass and digital images through eCSI portal)