Fluorescence in situ hybridization (FISH) aids in the detection of chromosome abnormalities that are below the level of resolution of conventional cytogenetics or associated with cells that do not divide in culture. FISH testing can detect cryptic or variant rearrangements involving specific chromosome loci and is often performed on uncultured cells. Thus, even if attempts to culture the cells for routine cytogenetics have failed, FISH can be performed to aid in diagnosis.

CSI Laboratories offers an extensive menu of molecular genetics assays for the diagnosis and monitoring of many diseases. For additional information regarding specific test offerings, please contact CSI Client Service or your local Account Manager.

ALK gene rearrangement - NSCLC
CSI Laboratories offers the FDA-approved Vysis® ALK Break Apart FISH Probe Kit from Abbott Molecular.  This assay detects rearrangements involving the ALK gene in formalin-fixed paraffin-embedded non-small cell lung cancer (NSCLC) tissue specimens. It is intended to aid in identifying those patients eligible for treatment with Xalkori® (crizotinib).

Hematopathology Assays
ALL – Acute lymphoblastic leukemia
AML – Acute myelogenous leukemia
CLL – Chronic lymphocytic leukemia
CML – Chronic myelogenous leukemia
MDS – Myelodysplastic syndrome
MPN – Myeloproliferative neoplasms
MM – Multiple myeloma
NHL – Non-Hodgkin lymphoma

Solid-Tumor Pathology Assays
ALK (FDA Approved) gene rearrangement - NSCLC
HER2 (PathVysion®) & TOP2A - Breast cancer
EGFR - Lung Cancer
PTEN - Colorectal cancer, Prostate cancer
UroVysion® - Bladder cancer
Alveolar Rhabdomyosarcoma
Ewing sarcoma
Neuroblastoma
Synovial sarcoma