Test Method


Disease Long Name

B-cell Lymphoma

Disease Abbreviation


CPT Code

88377xX (Global)
88374xX (Tech-only)

Probes / Test Description

DHL and THL always contain complex karyotypes and can be seen in diffuse (high grade) large B-cell lymphoma (DLBCL) or the newly created BCLu-DLBCL/BL (B-cell lymphoma, unclassifiable, with features intermediate between Diffuse (high grade) Large B-cell Lymphoma and Burkitt Lymphoma
IF clinically indicated for MCL,
REFLEX: t(6:14)/CCND3-IGH, t(11;14)/CCND1-IGH, CCND1-break-apart, CCND2-break-apart

Specimen Requirements

  • Bone marrow aspirate: 2-3 mL in sodium heparin (green top) preferred, or 1-2 mL in EDTA (purple top)
  • Peripheral blood: 3 mL in sodium heparin (green top) preferred, or 3 mL in EDTA (purple top)
  • Fresh Tissue: Multiple 2-3 mm pieces of tissue in RPMI transport media (optimum RPMI to tissue ratio is 15:1; (multiple vials are acceptable)
  • Formalin-Fixed Paraffin-Embedded Tissue: Minimum 0.2 x 0.2 x 0.2 cm tissue, non-decalcified tissue only

Storage & Transport

Ship specimen the same day whenever possible, with refrigerated (not frozen) cold pack.

Label all tubes with at least two unique patient identifiers. Slides require one patient identifier. Identifiers include name, DOB, specimen ID# or medical record#.

Turnaround time

3 - 5 days

Level of Service