Test Method


Disease Long Name

MALT Lymphoma, Extranodal Marginal Zone Lymphoma

Disease Abbreviation


CPT Code

88377x3 (Global)
88374x3 (Tech-only)

Probes / Test Description

MALT1-break-apart, BCL6-break-apart,t(11;18)/BIRC3-MALT1
IF MALT1 rearranged, REFLEX TO: t(14;18)/IGH-MALT1]

Specimen Requirements

  • Bone marrow aspirate: 2-3 mL in sodium heparin (green top) preferred, or 1-2 mL in EDTA (purple top)
  • Peripheral blood: 3 mL in sodium heparin (green top) preferred, or 3 mL in EDTA (purple top)
  • Fresh Tissue: Multiple 2-3 mm pieces of tissue in RPMI transport media (optimum RPMI to tissue ratio is 15:1; (multiple vials are acceptable)
  • Formalin-Fixed Paraffin-Embedded Tissue: Minimum 0.2 x 0.2 x 0.2 cm tissue, non-decalcified tissue only

Storage & Transport

Ship specimen the same day whenever possible, with refrigerated (not frozen) cold pack.

Label all tubes with at least two unique patient identifiers. Slides require one patient identifier. Identifiers include name, DOB, specimen ID# or medical record#.

Turnaround time

3 - 5 days

Level of Service