Test Method

IHC

CPT Code

88342 x 1
88341 x 1

Stains / Test Description

The ALK1 antibody is used to identify anaplastic large-cell lymphomas (ALCL) that are ALK positive by labeling normal human ALK protein and the NPM-ALK chimeric protein.

Specimen Requirements

Bone marrow aspirate: 2-3 mL in sodium heparin (green top) preferred, or 1-2 mL in EDTA (purple top)

Peripheral blood: 3 mL in sodium heparin (green top) preferred, or 3 mL in EDTA (purple top)

Fresh Tissue: Multiple 2-3 mm pieces of tissue in RPMI transport media (optimum RPMI to tissue ratio is 15:1; (multiple vials are acceptable)

Formalin-Fixed Paraffin-Embedded Tissue: Minimum 0.2 x 0.2 x 0.2 cm tissue, non-decalcified tissue only

Storage & Transport

Ship specimen same day (whenever possible) with refrigerated (not frozen) cold pack

Turnaround time

1-3 days depending on level of service

Level of Service

Global (with interpretation)
Slide Only (glass slides only)
Web-Enabled (glass and digital images through eCSI portal)