Test Method


CPT Code

88342 x 1
88341 x 1

Stains / Test Description

The BCL6 antibody stains the follicular cells and interfollicular cells in follicular lymphoma, germinal center cells in lymphoid follicles, some types of diffuse large B-cell lymphomas, Burkitt lymphoma, and the majority of Reed-Sternberg cells in nodular lymphocyte predominant Hodgkin lymphoma. Conversely, BCL6 rarely stains mantle cell lymphoma and MALT lymphoma. While BCL6 expression is seen in approximately half of CD30+ anaplastic large cell lymphomas, it is absent in other peripheral T-cell lymphomas.

Specimen Requirements

(1) H&E slide with formalin-fixed, paraffin-embedded (FFPE) tissue, fixed with 10% NBF.
One (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4 microns) for each test/antibody ordered

Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.

Storage & Transport

Ship specimen same day (whenever possible) with refrigerated (not frozen) cold pack

Turnaround time

1-3 days depending on level of service

Level of Service

Global (with interpretation)
Slide Only (glass slides only)
Web-Enabled (glass and digital images through eCSI portal)