Test Method


CPT Code

88342 x 1
88341 x 1

Stains / Test Description

Two glycoproteins of 34 and 49 kDa present on the surface and the cytoplasm of all epithelial cells are recognized by Ber-EP4 (except for the superficial layers of squamous epithelial, hepatocytes and parietal cells). It shows a broad spectrum of reactivity with human epithelial cells such as simple epithelia and basal layers of stratified non-keratinized squamous epithelium and epidermis, however it rarely marks mesoepithelial cells. Ber-EP4 can differentiate adenocarcinomas from pleural mesotheliomas

Specimen Requirements

(1) H&E slide with formalin-fixed, paraffin-embedded (FFPE) tissue, fixed with 10% NBF.
One (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4 microns) for each test/antibody ordered

Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.

Storage & Transport

Ship specimen same day (whenever possible) with refrigerated (not frozen) cold pack

Turnaround time

1-3 days depending on level of service

Level of Service

Global (with interpretation)
Slide Only (glass slides only)
Web-Enabled (glass and digital images through eCSI portal)