Test Method


CPT Code

88342 x 1
88341 x 1

Stains / Test Description

While beta-catenin is an important regulator of cell–cell adhesion and embryogenesis, mutations of it may lead to some human cancers. Normal cells show membrane staining for beta-catenin, while cytoplasmic and/or nuclear staining is abnormal. Dysregulation of beta-catenin occurs in Gardner syndrome, leading both to familial adenomatous polyposis and fibromatosis. Nuclear location of beta-catenin is also present in colon and endometrioid ovarian carcinomas, synovial sarcoma, osteosarcoma, liposarcoma, palisaded myofibroblastoma, and other sarcomas.

Specimen Requirements

(1) H&E slide with formalin-fixed, paraffin-embedded (FFPE) tissue, fixed with 10% NBF.
One (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4 microns) for each test/antibody ordered

Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.

Storage & Transport

Ship specimen same day (whenever possible) with refrigerated (not frozen) cold pack

Turnaround time

1-3 days depending on level of service

Level of Service

Global (with interpretation)
Slide Only (glass slides only)
Web-Enabled (glass and digital images through eCSI portal)