Test Method


CPT Code

88342 x 1
88341 x 1

Stains / Test Description

The IHC demonstration of calcitonin is can identify early or microscopic medullary thyroid cancer (MTC), identify an MTC in the absence of amyloid deposits, distinguish non-typical forms of MTC (e.g., predominantly spindle cell or small cell patterns) from anaplastic carcinoma or malignant lymphoma, differentiate MTC with microfollicular or papillary patterns from thyroid follicular and papillary neoplasms, and identify C-cell hyperplasia in association with hypercalcemia of diverse etiologies.

Specimen Requirements

(1) H&E slide with formalin-fixed, paraffin-embedded (FFPE) tissue, fixed with 10% NBF.
One (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4 microns) for each test/antibody ordered

Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.

Storage & Transport

Ship specimen same day (whenever possible) with refrigerated (not frozen) cold pack

Turnaround time

1-3 days depending on level of service

Level of Service

Global (with interpretation)
Slide Only (glass slides only)
Web-Enabled (glass and digital images through eCSI portal)