Test Method
IHC
CPT Code
88344
Stains / Test Description
The combination of p63 + CK HMW + P504S (PIN-4 cocktail) can be extremely useful for diagnosing prostatic intraepithelial neoplasia (PIN) and/or prostate carcinoma, especially in difficult cases with limited tissue. P504 stains (cytoplasm red) prostate adenocarcinoma and atypical adenomatous hyperplasia. p63 (nuclear brown) and cytokeratin high molecular weight (HMW, cytoplasmic brown) stain basal cells of all normal (negative markers) and benign prostate glands.
Specimen Requirements
(1) H&E slide with formalin-fixed, paraffin-embedded (FFPE) tissue, fixed with 10% NBF.
or
One (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4 microns) for each test/antibody ordered
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
or
One (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4 microns) for each test/antibody ordered
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Storage & Transport
Ship specimen same day (whenever possible) with refrigerated (not frozen) cold pack
Turnaround time
1-3 days depending on level of service
Level of Service
Global (with interpretation)
Slide Only (glass slides only)
Web-Enabled (glass and digital images through eCSI portal)
Slide Only (glass slides only)
Web-Enabled (glass and digital images through eCSI portal)