NGS Solid Tumor PLUS Profile

Molecular

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The Solid Tumor PLUS Panel is designed to provide the most comprehensive, actionable profiling available of molecular abnormalities in various solid tumors including carcinomas of the lung, gastric, pancreas, brain, colon, breast, ovary, endometrium, thyroid, melanoma, head and neck tumors, and sarcomas. Most importantly, this test especially includes numerous translocations and fusions, such as, NTRK, ALK, RET, ROS1, BRAF, PAX8, PPARG, TMPRSS2, MET exon 14 skipping, and others as well as amplification of HER2, FGFR, MET, MYC, MDM2, and others. This Solid Tumor Plus Panel is particularly important for diagnosis and classification of brain and thyroid cancers. The RNA testing component encompasses 1408 genes and provides information on fusion, expression levels and profile as well as mutations. The DNA testing component covers abnormalities in single-nucleotide (SNV) and indels in 434 genes as well as copy number variation (CNV). In addition, DNA testing is designed to detect microsatellite instability (MSI) and tumor mutational burden (TMB) and will also be reported. The provided information helps in determining cell or origin, prognosis, design therapeutic approaches and predict responses to therapy

• Formalin-Fixed Paraffin-Embedded Tissue: 1 H&E slide cut to 4 microns and 6-8 slides cut at 8 microns of BM clot or tissue fixed with 10% NBF fixative on non-charged slides. Please circle tumor for microdissection. Alternatively, the FFPE clock of the BM clot can be sent for sectioning in our lab.

Ship specimen the same day whenever possible, with refrigerated (not frozen) cold pack.

Label all tubes with at least two unique patient identifiers. Slides require one patient identifier. Identifiers include name, DOB, specimen ID# or medical record#.

7 -10 days

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