PCR-based microsatellite analysis for 1p19q deletion status and identification of loss of heterozygosity (LOH).
Alpha-1-Antitrypsin (AAT) is used to screen for inherited AAT deficiency, benign and malignant hepatic tumors and yolk sac carcinoma, as well as some other forms of liver disease.
Testing by RT-PCR and sequencing of the BCR-ABL1 fusion transcript for qualitative detection of mutations associated with resistance to tyrosine kinase inhibitors. Analysis includes detection of the common T315I mutation. Recommended for CML.
Adrenocorticotropic hormone (ACTH) is used to classify pituitary tumors and pituitary disease. It reacts with ACTH-producing cells (corticotrophs) and some other tumors such as certain small cell lung carcinomas
This antibody targets viruses that multiply in the cell nucleus and can cause latent infections in tonsils, adenoids and other lymphoid tissues.
AE1 is used for the diagnostic distinction of anaplastic carcinoma from lymphoma and melanoma in routinely processed tissues. It recognizes various keratin polypeptides distributed in a wide variety of epithelia.
Monoclonal antibodies AE1 and AE3 in combination can detect almost all human epithelia. through recognition of the acidic and basic subfamilies of cytokeratin. The cocktail is used to confirm or rule out the epithelial nature of tissue, tumors or components of tumors, or to differentiate epithelial from non-epithelial tumors.
Special stain. The Acid-Fast Bacilli Stain is used to identify acid-fast organisms, mainly Mycobacteria. The most significant disease-producing mycobacteria are Mycobacterium tuberculosis and Mycobacterium leprae (leprosy).
AFP is helpful in diagnosing hepatocellular carcinoma. Alpha-1-fetoprotein (AFP) is a 64 kD tumor-associated embryonal antigen produced by fetal liver, hepatocellular carcinoma, yolk sac tumor and some germ cell tumors of testicular and ovarian origin. Most non-seminomatous germ cell tumors produce AFP.