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CK8/18 (Cytokeratin 8/18)
Cytokeratins 8 & 18 can be found in most simple epithelium, e.g. thyroid, female breast, gastrointestinal tract, and respiratory tract. Adenocarcinomas and most non-keratinizing squamous carcinomas will stain, but keratinizing squamous carcinomas will not. This antibody is used when attempting to demonstrate the presence of Paget cells; there is very little keratin 18 in the normal epidermis so this will only stain Paget cells. This approach facilitates the interpretation using immunostains and is more sensitive than mucin histochemistry.
CK903 (34BE12)
CK903 (34betaE12) is a high molecular weight cytokeratin present in all squamous epithelium and their carcinomas. This antibody recognizes cytokeratins 1, 5, 10 and 14 that are found in complex epithelia. There has been no reactivity with cells derived from simple epithelia, mesenchymal tumors, lymphomas, melanomas, neural tumors and neuroendocrine tumors. One useful application is the identification of the basal cell layer in prostate tissue in the determination of carcinoma.
CLL/MCL
CLL1/(ATM/TP53), CLL2/(13q14.3/LAMP1/CEP12),IGH-break-apart, MYB-CEP6, RB1-LAMP1, t(11;14)/CCND1-IGH
IF IGH Rearranged, REFLEX: t(14;18)/IGH-BCL2 -
IF unresolved question of MCL, REFLEX: [t(6:14)/CCND3-IGH, CCND1-break-apart, CCND2-break-apart]
CLL/SLL
CLL1/(ATM/TP53), CLL2/(13q14.3/LAMP1/CEP12),IGH-break-apart, MYB-CEP6, RB1-LAMP1
IF IGH Rearranged, REFLEX: [t(11;14)/CCND1-IGH] and/or [t(6:14)/CCND3-IGH, t(14;18)/IGH-BCL2,CCND2-break-apart] if indicated
CML (BCR-ABL)
t(9;22)/BCR-ABL1
IF POSITIVE, REFLEX: (BCR-ABL1(p210/p190) by RT-PCR
CMV by IHC (Cytomegalovirus)
Cytomegalovirus (CMV) is an opportunistic pathogen infecting lung, kidney, gut and other organs in situations where an individual is immunologically immature, such as the fetus and neonate. Infection also occurs in immunosuppressed patients, e.g. transplant patients, patients undergoing chemotherapy and HIV infected patients.
COLL IV (Collagen Type IV)
Collagen Type IV is the major component of the basal lamina so antibodies to this molecule confirm its presence and reveal the morphological appearance of the structure. Normal tissue stains with this antibody in a fashion consistent with the sites of mesenchymal elements and epithelial basal laminae. Anti-Collagen IV can also be useful in the classification of soft tissue tumors; schwannomas, leiomyomas. Their well differentiated, malignant counterparts usually immunoreact with this antibody. The vascular nature of neoplasms, hemangiopericytoma, angiosarcoma and epithelioid hemangioendothelioma can be revealed by this antibody with greater reliability than non-specific stains (e.g. silver reticulum).