Found 383 Results - Page 35 of 39
Surfactant Apoprotein-A
Pulmonary surfactant apoproteins play essential roles in keeping alveoli from collapsing at the end of expiration. SP-A is located mainly in type II pneumocytes and has been demonstrated in bronchiolo-alveolar carcinomas and adenocarcinomas of the lung. Mesotheliomas show no positive staining with this antibody. Surfactant can be helpful in the differential diagnosis of pulmonary adenocarcinomas and mesotheliomas.
SV40 Large T Antigen
Simian Virus 40 (SV40) is a polyomavirus that is found in both monkeys and humans. Like other polyomaviruses, SV40 is a DNA virus that has the potential to cause tumors. SV40 is believed to suppress the tumor-suppressing p53 in humans. A mutated p53 gene may contribute to uncontrolled cellular proliferation, leading to a tumor. The hypothesis that SV40 might cause cancer in humans has been a particularly controversial area of research. Some research has suggested that SV40 is associated with brain tumors, bone cancers, non-Hodgkin lymphoma and malignant mesothelioma. This antibody shows cross-reactivity to BK and JC virus, and some use it a surrogate to detect these viruses. 
This antibody is designed to qualitatively detect the presence of synaptophysin expressing cells via light microscopy in formalin fixed, paraffin embedded tissue. Positive staining results may aid in the classification of neuroendocrine tumors.
[t(9;22)/BCR-ABL1, (9p21)/CDKN2A-CEP9, KMT2A(MLL)-Breakapart]
*IF NEGATIVE and NORMAL karyotype, REFLEX TO: [14q11.2 TRA, 7q34 TRB, 10q24 TLX1, 5q35 TLX3, 10p12 MLLT10, 11q21 PICALM, 1p33 TAL1/STIL]
T-Cell Receptor Beta Gene Rearrangement
This test provides qualitative detection of monoclonal T-cell receptor (TCR) beta gene rearrangements by PCR and fragment analysis and can improve TCR rearrangement detection by ~5% in T-cell leukemias/lymphomas.
T-cell Receptor Gamma Gene Rearrangement
This test provides detection of clonal T-cell receptor gamma (TCRG) gene rearrangements by PCR of variable and joining regions. T-Cell Receptor Beta Gene Rearrangement is offered separately and may be added to this gamma gene test.