The histochemical identification of hairy cell leukemia via tartrate-resistant acid phosphatase assay has been a standard for over two decades. Anti-TRAcP antibody labels the cells of hairy cell leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts, which also express abundant TRAcP activity.
Spirochete (Treponema pallidum) is the causative agent of syphilis. In the past, localization of the spirochete agent was achieved with silver stains such as Steiners and/or Warthin-Starry. Treponema pallidum can now be successfully localized with IHC techniques in FFPE tissue. The antibody is highly specific for spirochete. Treponema palladium also cross-reacts with Borrelia burgdorferi (Lyme disease).
Trypsin is a serine protease found in the digestive system of many vertebrates where it hydrolyses proteins. Trypsin cleaves peptide chains mainly at the carboxyl side of the amino acids lysine or arginine, except when either is followed by proline. Trypsin is formed in the small intestine when its proenzyme form, the trypsinogen produced by the pancreas, is activated. Trypsin-1, also known as cationic trypsinogen, is the main isoform of trypsinogen secreted by the pancreas. Trypsin-2 is also known as anionic trypsinogen, and Trypsin-3 is also known as meso- trypsinogen.
Tryptases constitute a subfamily of trypsin-like proteinases, stored in the mast cell secretory granules and basophils. Upon cellular activation, these enzymes are released into the extracellular environment. Anti-tryptase is a good marker for mast cells, basophils, and their derivatives.
Antibody MAB4130 recognizes a 36 kDa protein identified as Thymidylate Synthase [TS], which is a target for the fluoropyrimidine group of antineoplastic drugs used to treat solid tumors. Expression of TS is associated with response to 5-fluorouracil (5-FU) in human breast, colorectal, gastric, head and neck carcinomas.
Anti-TSH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with TSH-producing cells (thyrotrophs.)
Anti-Thyroid Transcription Factor Primary Antibody is designed to qualitatively detect the presence of thyroid transcription factor-1 (TTF-1) expressing cells. TTF-1 positive staining results may aid in the classification of neoplasms of the lung and thyroid.
This antibody is designed to qualitatively detect the presence of tyrosinase expressing cells via light microscopy in formalin fixed, paraffin embedded tissue. Positive results aid in the classification of melanoma.