Long the cornerstone of genetic testing, cytogenetics analyzes the entire chromosome set for numerical and structural abnormalities such as chromosome additions, deletions and translocations. Identification of each abnormality aids diagnosis and treatment decisions for cancer patients. Cytogenetics requires interpretation by a skilled and experienced board-certified cytogeneticist–analysis of leukemias, lymphomas, and solid tumors often reveals otherwise undetectable chromosome abnormalities that might alter the diagnosis, prognosis, and therapeutic approach.
The cytogenetics team at CSI Laboratories is staffed by highly skilled PhDs and cytogenetic technologists. Each case is carefully reviewed to determine the most appropriate culturing methods and specific mitogens necessary to stimulate B-cell and T-cell lymphomas and plasma cell neoplasia samples in cytogenetic cultures. Our methods consistently provide our clients with reliable and informative cytogenetic results including tests on lymph nodes, which may be considered difficult samples to work with by other laboratories. All findings are correlated with other ancillary results to further help the pathologist in the morphologic evaluation of a particular neoplasm.
Test results that exceed COG approval standards
CSI’s cytogenetic laboratory is approved by the Children’s Oncology Group (COG) to perform cytogenetic analysis of pediatric oncology specimens—yet another example of our commitment to provide you with the highest-quality diagnostic service. An approval by COG is reserved for a limited number of laboratories who exceed their high standards. The COG approval process requires laboratories to meet or exceed a cytogenetic abnormality detection rate of at least 55% for samples submitted on an ongoing basis; CSI consistently returns detection rates that exceed the abnormality threshold.
- Chromosomes analysis of leukemias, lymphomas, and solid tumors, as well as constitutional analysis
- Use of specific mitogens to stimulate B-cell and T-cell lymphomas
- Chromosome analyses of constitutional studies, including Products of Conception (POC)
- Lab approval by the Children’s Oncology Group (COG)
- Exceptional abnormality detection rates